Archives
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The MOF system described by Farha
2021-06-19
The MOF system described by Farha and coworkers combines rational design of the support and good experimental results regarding activity and stability. However, a further increase in the speed of enzyme loading into the MOF and a decrease in leaching are still required. How can the design rules prop
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Docking experiments showed that Me MeGlcA Xyl and MeGlc
2021-06-19
Docking experiments showed that Me-MeGlcA3Xyl4 and MeGlc3Xyl4 were bound to EcXyn30A and the R293A variant in the same way as MeGlcA3Xyl4, having MeGlcA or its modified forms accommodated in the -2b subsite. All ligands were coordinated by the same Bisindolylmaleimide VIII acetate and no new intera
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br Ultrasonic pretreatment of substrates Substrate pretreatm
2021-06-19
Ultrasonic pretreatment of substrates Substrate pretreatment is widely used in the biofuel, textile and food industries since the substrates are always difficult to degrade. During some enzymatic hydrolysis reactions, the protective layer of the substrate impedes the reaction. Ultrasonic treatmen
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The elastase induced injury model has been shown to
2021-06-19
The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat
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br Abbreviations br Introduction br Collagen induced DDR
2021-06-19
Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III
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Amyloid Beta-peptide (25-35) australia The significance of t
2021-06-19
The significance of the difference in the DDR2 binding specificity towards fibrillar and non-fibrillar collagens is not understood, but may imply differences in biological responses when chondrocytes bind to different collagens in the growth plate. Investigations by Labrador et al. (2001) have shown
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In principle in vitro techniques for assessing enzyme
2021-06-19
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Calpain Inhibitor XII lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with reco
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In conclusion we demonstrate that infection of
2021-06-19
In conclusion we demonstrate that infection of salmon cells with ISAV induce the main branches of the cellular UPR machinery, but also one of its main negative regulators, GADD34. This is probably important for maintaining translation of interferon and interferon stimulated genes (ISGs), keeping ISA
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br Materials and methods br Results br Discussion UPP
2021-06-19
Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important Ion Channel Compound Library mg of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the
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Another example of negative regulation is the inhibition of
2021-06-19
Another example of negative regulation is the inhibition of the yeast endosome-associated DUB Doa4 by Rfu1 (free ubiquitin chains 1). In a yeast genetics screen, deletion of Rfu1 was serendipitously found to alter global ubiquitin levels [69]. DUBs can regulate these levels by liberating conjugated
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br Acknowledgements We thank Dr James Ritchie and his dedica
2021-06-19
Acknowledgements We thank Dr. James Ritchie and his dedicated staff (Deptartment of Pathology, Emory University) for performing measures of serum VPA levels; Sumitomo Pharmaceuticals (Osaka, Japan) for the generous donation of DOPS, which is required for breeding Dbh −/− mice; Pfizer (Sandwich, K
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br Introduction As a strong analgesic morphine is often used
2021-06-19
Introduction As a strong analgesic, morphine is often used to treat acute and chronic pain. However, morphine is a substance with low lipid solubility that slowly enters the nerve tissue through the blood–brain barrier and produces neurotoxicity. Morphine-induced neurotoxicity can be produced aft
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Our data supports the conclusion that the
2021-06-19
Our data supports the conclusion that the exonuclease activity thought to be intrinsic to Artemis is not a component of the Artemis polypeptide. Many possibilities exist to explain the presence of the exonuclease activity in less-pure fractions of Artemis. It is possible that the exonuclease is simp
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In contrast to G and G which are
2021-06-19
In Calyculin A to G468 and G469, which are buried (Fig. 7a), residues 470–476 are equivalent to the surface loop L12 present in the crystal structure of the LigI complex (Fig. 7b) [17]. The OBD of DNA ligases adopts at least two distinct orientations during the catalytic cycle. In the adenylation s
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br Acknowledgements br Introduction Serum triglyceride conce
2021-06-19
Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr