Archives
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br Material and methods br Results br Discussion Isolated
2020-10-23
Material and methods Results Discussion Isolated ARCA Cy3 EGFP have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, th
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br Materials and methods br Results
2020-10-23
Materials and methods Results Discussion We recently detected phosphorylation of tyrosine Y102 in BPV-1 E2 and reported that FGFR3 binds to E2 and limits E1 dependent viral DNA replication (Culleton et al., 2017, Xie et al., 2017). In the current study, we addressed the potential role of ot
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Funding sources This study was funded by
2020-10-23
Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg
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In LPS treated BV cells we found
2020-10-23
In LPS-treated BV-2 cells, we found that the upregulated CysLT2R was translocated into the nucleus. The nuclear localization of CysLT2Rs in microglia has not been reported previously. It is known that CysLT1Rs in endothelial Sarpogrelate hydrochloride translocated to the nucleus in a ligand-independ
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p Kip is a critical component of the
2020-10-23
p27Kip1 is a critical component of the cell cycle machinery [15]. As an inhibitor of cyclin E-Cdk2, p27Kip1 plays a pivotal role in controlling cell proliferation, S-phase entry, and G1-phase exit during development and tumorigenesis [16]. p27Kip1 is predominantly regulated via posttranslational mod
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br Conclusion This patient was hypercoaguable as evidenced b
2020-10-23
Conclusion This patient was hypercoaguable as evidenced by a lower extremity DVT, pulmonary emboli, and a splenic infarct. Excluding acute CMV infectious mononucleosis, she had no disorders predisposing to splenic infarcts.4, 5 In this case, CMV infectious mononucleosis was accompanied by CMV lun
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Berner et al used a meta analysis to show
2020-10-23
Berner et al used a meta-analysis to show that sildenafil resulted in an effect of 9.65-point improvement. Tadalafil could be pooled into an effect of 8.52-point improvement, and vardenafil showed an effect of 7.50-point improvement. In our present studies, 200 mg udenafil resulted in an effect of 8
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gsk products br Discussion The regulation of intracellular c
2020-10-23
Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec
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During the past decade it became increasingly clear that the
2020-10-22
During the past decade, it became increasingly clear that the affinity and efficacy of small agonists acting on the orthosteric binding site of a GPCR can be modulated by ligands that bind to a topographically distinct (allosteric) binding site on the same GPCR molecule 33, 39, 40, 41, 42. This allo
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Vanoxerine dihydrochloride br Neurodegenerative diseases def
2020-10-22
Neurodegenerative diseases: definition and categories Diseases that their progression is dependent on the formation of protein aggregates, are generally identified as protein aggregation diseases. Most common among them is neurodegenerative diseases, in which the protein abnormally Vanoxerine dih
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In this context we initiated a program
2020-10-22
In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in protease activated receptor replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrot
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It is interesting to note that oligomerization of recombinan
2020-10-22
It is interesting to note that oligomerization of recombinant DDR1 ECD primarily occurred when the protein was incubated with collagen in solution and to a much lesser extent when collagen was pre-immobilized on a surface as reported in our earlier studies (Agarwal et al., 2007). We believe that pre
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Pathological changes in animal are powerful indicators of th
2020-10-22
Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin
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The associations between genetic factors and socio emotional
2020-10-22
The associations between genetic factors and socio-emotional functioning are complex and almost certainly not direct. They are mediated through a variety of developmental processes including individual differences in personality traits (Davis and Loxton, 2013, Saphire-Bernstein et al., 2011). For th
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br Experimental br Declaration of interest br Introduction
2020-10-22
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR olmesartan medoxomil library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was